Publication Author / Jornal
 Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive
Agent for Skin Photoaging and Phontoinduced Skin Cancers
González S. et al. / International Journal of Molecular Sciences, 2011, 12,
 Current Trends in Photoprotection - A New Generation of Oral PhotoprotectorsGonzález S. et al. / The Open Dermatology Journal, 2011, Vol. 5, 1-9                    
 Oral polypodium leucotomos extract photoprotective activity in 57 patients with
idiopathic photodermatoses
Caccialanza M., Recalcati S., Piccinno R./ Giornale Italiano di Dermatologia e
Venereologia, 2011, Vol. 146 No. 2, 85-87
 Oral administration of a hydrophilic extract of Polypodium leucotomos for the
prevention of polymorphic light eruption
Tanew A. et al. / Journal of the American Academy of Dermatology, 2011,
Article in press
 Mechanistic insights in the use of a Polypodium leucotomos extract as an oral
and topical photoprotective agent
González S., Gilaberte Y., Philips N. / Photochemical and Photobiological
Sciences, 2010, 9, 559–563
 Polypodium leucotomos extract: A natural antioxidant and photoprotective tool
for the management of UV-induced skin damage and phototherapy
González S. / Cosmetic Dermatology, 2009, Vol. 22, No. 12
 Polypodium Leucotomos Extract Decreases UV-Induced Cox-2 Expression and
Inflammation, Enhances DNA Repairs, and Decreases Mutagenesis in Hairless Mice
Zattra E. et al. / The American Journal of Pathology, 2009,
Vol. 175, No. 5, 1952-1961
 Cancer cell growth and extracellular matrix remodeling mechanism of ascorbate;
beneficial modulation by P. leucotomos
Philips N., Dulaj L., Upadhya T. / Anticancer Research, 2009,
No.: 10158-P, 29(8):3233-3238
 Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar
collagens and transforming growth factor-b by Polypodium leucotomos, directly
or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells
Philips N. et al. / Archives of Dermatological Research,
2009, Aug, 301(7), 487-95
 Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppressionSiscovick JR. et al. / Photodermatology, Photoimmunology +
Photomedicine, 2008, 24, 134–141
 Photoprotective activity of oral polypodium leucotomos extract in 25 patients with
idiopathic photodermatoses
Caccialanza M. et al. / Photodermatology, Photoimmunology +
Photomedicine, 2007, 23, 46–47
 Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium
leucotomos extract: a randomized double-blind placebo-controlled study
Middelkamp-Hup MA. et al. / Journal of European Academy of
Dermatology and Venereology, 2007, 21, 942–950
 Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization
and photodecomposition
Capote R. et al. / Journal of Photochemistry and Photobiology,
2006, 82, 173-179
 Oral Polypodium leucotomos extract decreases ultraviolet-induced damage
of human skin
Middelkamp-Hup MA. et al. / Journal of the American Academy of
Dermatology, 2004, Vol. 51 No. 6
 Orally administered Polypodium leucotomos extract decreases
psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin
Middelkamp-Hup MA. et al. / Journal of the American Academy of
Dermatology, 2004, Vol. 50 No. 1
 Predominant effects of Polypodium leucotomos on membrane integrity,
lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in
ultraviolet radiation exposed fibroblasts, and keratinocytes
Philips N. et al. / Journal of Dermatological Science, 2003, 32, 1-9
 The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions
with reactive oxygen species
Gomes AJ. et al. / Brazilian Journal of Medical and Biological Research,
2001, 34, 1487-1494
 An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines
balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic
relationships and therapeutic implications
 González S. et al. / Anticancer Research, 2000, 20, 1567-1576
 Topical or oral administration with an extract of Polypodium leucotomos prevents
acute sunburn and psoralen-induced phototoxic reactions as well as depletion
of Langerhans cells in human skin
González S. et al. / Photodermatology, Photoimmunology + Photomedicine,
1997, 13, 50-60
 Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid
peroxidatio, erythema and skin photosensitization by polypodium leucotomos
González S, Pathak MA. / Photodermatology, Photoimmunology +
Photomedicine, 1996, 12, 45-56